ESPE Abstracts

Background: Among other cytokines, the hepatokine fibroblast growth factor 21 (FGF21) and the myokine irisin have been considered potential biomarkers for insulin sensitivity (IS). In adult studies, both of them have been found elevated in insulin resistant states.Objective and hypotheses: Our aim was to study whether serum FGF21 and irisin associate with markers of insulin sensitivity (IS) and serum lipids in 12-year-old children....

Background: Osteocalcin (OC) is an osteoblast derived marker of bone turnover, but it has also been linked to glucose metabolism. Specifically, the undercarboxylated form of OC has been proposed to act as a hormone that links bone to glucose homeostasis.Objective and hypotheses: Our aim was to study whether serum total OC associates with insulin sensitivity in 12-year-old children.Subjects and methods: A total of 192 children (109 ...

Background: Elevated concentrations of interleukin 1 – receptor antagonist (IL-1Ra) have been found in adult subjects with the metabolic syndrome and type 2 diabetes as a marker of inflammation.Objective and hypotheses: Our aim was to study whether serum IL-1Ra associates with markers of reduced insulin sensitivity (IS) and dyslipidemia in 12-year-old children.Method: A total of 192 children (109 girls) were studied at the mea...